January 6, 2020

Alan F. Joslyn, Ph.D.
Chief Executive Officer
Oragenics, Inc.
4902 Eisenhower Blvd., Suite 125
Tampa, FL 33634

       Re: Oragenics, Inc.
           Registration Statement on Form S-3
           Filed December 31, 2019
           File No. 333-235763

Dear Dr. Joslyn:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Paul Fischer at 202-551-3415 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of Life
Sciences
cc:    Mark Catchur, Esq.