United States securities and exchange commission logo August 8, 2022 Michael Sullivan Chief Financial Officer Oragenics, Inc. 4902 Eisenhower Blvd, Suite 125 Tampa, Florida 33634 Re: Oragenics, Inc. Form 10-K for the Fiscal Year Ended December 31, 2021 Filed March 24, 2022 File No. 001-32188 Dear Mr. Sullivan: We have completed our review of your filing. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Sincerely, Division of Corporation Finance Office of Life Sciences