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                          January 19, 2023

       Kimberly Murphy
       Chief Executive Officer
       ORAGENICS INC
       4902 Eisenhower Boulevard, Suite 125
       Tampa, FL 33634

                                                        Re: ORAGENICS INC
                                                            Registration
Statement on Form S-3
                                                            Filed January 13,
2023
                                                            File No. 333-269225

       Dear Kimberly Murphy:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Lauren
Hamill at 303-844-1008 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Mark Catchur