EXHIBIT 5.1


                   [SHUMAKER, LOOP & KENDRICK, LLP LETTERHEAD]


                                November 21, 2003


Oragenics, Inc.
12085 Research Drive
Alachua, Florida  32615

         Re: Registration Statement on Form S-8

Sir or Madam:

         We have assisted Oragenics, Inc., a Florida corporation (the "Company")
in connection with the preparation and filing of its Registration Statement on
Form S-8 with the Securities and Exchange Commission pursuant to the
requirements of the Securities Act of 1933, as amended (the "Act"), for the
registration of an aggregate of 1,000,000 shares of the common stock of the
Company, par value $.001 per share (the "Shares"), issuable under the Company's
2002 Stock Incentive Plan, (the "Plan").

         In connection with the following opinion, we have examined and have
relied upon such documents, records, certificates, statements and instruments as
we have deemed necessary and appropriate to render the opinion herein set forth.

         We assume that the appropriate action, if required, will be taken to
register and qualify the Shares for sale under all applicable state securities
or "blue sky" laws.

         Based upon the foregoing, it is our opinion that the Shares have been
duly authorized for issuance and when issued, delivered and paid for in
accordance with the terms and conditions of the Plan, the Shares will be legally
issued, fully paid and nonassessable.

         We are admitted to practice in the State of Florida. This opinion
letter is limited to the laws of the State of Florida, and the federal laws of
the United States of America as such laws presently exist and to the facts as
they presently exist. We express no opinion with respect to the effect or
applicability of the laws of any other jurisdiction. We assume no obligation to
revise or supplement this opinion letter should the laws of such jurisdictions
be changed after the date hereof by legislative action, judicial decision or
otherwise.

         The undersigned hereby consents to the filing this opinion as Exhibit
5.1 to the Registration Statement on Form S-8 and to the use of its name in the
Registration Statement. In giving such consent we do not admit that we are in
the category of persons whose consent is required under Section 7 of the Act.

                                       Very truly yours,


                                       /s/ Shumaker, Loop & Kendrick, LLP
                                       SHUMAKER, LOOP & KENDRICK, LLP