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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
     PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934

                                OCTOBER 13, 2004

                Date of Report (Date of earliest event reported)

                                 ORAGENICS, INC.

             (Exact name of registrant as specified in its charter)

          FLORIDA                      000-50614                59-3410522

(State or other jurisdiction          (Commission              (IRS Employer
      of incorporation)               File Number)           Identification No.)

                              12085 RESEARCH DRIVE
                             ALACHUA, FLORIDA 32615

           (Address of principal executive offices including zip code)

                                 (386) 418-4018

               Registrant's telephone number, including area code

                                      NONE

         (Former name or former address, if changed since last report.)
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ITEM 7.01         REGULATION FD DISCLOSURE

      Oragenics, Inc. announced today that it will present a corporate update at
the Rodman & Renshaw Techvest 6th Annual Healthcare Conference in New York City
later this month.

ITEM 9.01         FINANCIAL INFORMATION AND EXHIBITS

                  EXHIBIT NO.          DESCRIPTION

                  99.1                 Press Release


                                   SIGNATURES

      In accordance with the requirements of the Exchange Act, the registrant
caused this report to be signed on its behalf by the undersigned, thereunto duly
authorized on this 13th day of October, 2004.


                                       ORAGENICS, INC.
                                       (REGISTRANT)

                                       BY: /s/ Mento A. Soponis

                                           Mento A. Soponis
                                           President and Chief Executive Officer