FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
HILLMAN JEFFREY D
   2. Issuer Name and Ticker or Trading Symbol
ORAGENICS INC [ONI] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director __X__ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chief Scientific Officer
(Last)
(First)
(Middle)
13700 PROGRESS BLVD.		 3. Date of Earliest Transaction (Month/Day/Year)
12/30/2004
(Street)

ALACHUA, FL 32615		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 12/10/2004   G   7,000 (1) D $ 0 4,274,772 I By 2002 Trust
Common Stock 12/23/2004   G V 389,142 (2) D $ 0 670,444 I By GRAT
Common Stock 12/30/2004   G V 2,226,862 (3) D $ 0 2,430,052 I By 2002 Trust
Common Stock               2,226,862 I By FLITE

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
HILLMAN JEFFREY D
13700 PROGRESS BLVD.
ALACHUA, FL 32615		   X   X   Chief Scientific Officer  

Signatures

 /s/ Jeffrey D. Hillman   01/03/2005
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Since the reporting person's last report, 7,000 shares previously owned by Jeffrey D. Hillman, Trustee of the Jeffrey D. Hillman 2002 Trust ("2002 Trust") were gifted to Harvard University.
(2) Since the reporting person's last report, 389,142 shares previously owned by Jeffrey D. Hillman, as Trustee of the Jeffrey D. Hillman Grantor Retained Annuity Trust ("GRAT") have been transferred to 2002 Trust.
(3) Since the reporting person's last report, 2,226,862 shares previously owned by Jeffrey D. Hillman, Trustee of the Jeffrey D. Hillman 2002 Trust have been contributed to a FLITE trust known as "Stephanie C. Haas, Trustee of the Jeffrey D. Hillman Irrevocable Trust".

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