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               ORAGENICS,
                INC. 
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               (Exact
                name of registrant as specified in its charter) 
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               Florida 
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               000-50614 
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               59-3410522 
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               (State
                or other jurisdiction of incorporation) 
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               (Commission
                File Number) 
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               (IRS
                Employer Identification No.) 
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               13700 Progress
                Boulevard, Alachua, Florida 32615 
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               (Address
                of principal executive offices)(Zip Code) 
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               Registrant’s
                telephone number, including area code: (386)
                418-4018 
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               Not
                applicable 
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               (Former
                name or former address, if changed since last report) 
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               Exhibit
                No. 
             | 
            
               Description 
             | 
          
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               99.1 
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               Press
                Release of Oragenics, Inc. dated December 5,
                2008. 
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               December
                5, 2008 
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               ORAGENICS,
                INC. 
              By:   
                /s/
                David B.
                Hirsch                        
                 
              David
                B. Hirsch 
              Chief
                Financial Officer 
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