| 
               FL 
             | 
            
               001-38122 
             | 
            
               59-3410522 
             | 
          ||
| 
               (State
      or other jurisdiction 
              of
      incorporation) 
             | 
            
               (Commission
      File Number) 
             | 
            
               (IRS
      Employer 
              Identification
      Number) 
             | 
          
| 
               13700
      Progress Blvd 
             | 
            
               32615 
             | 
          |
| 
               (Address
      of principal executive offices) 
             | 
            
               (Zip
      Code) 
             | 
          
| 
               ¨ 
             | 
            
               Written
      communications pursuant to Rule 425 under the Securities Act (17 CFR
      230.425) 
             | 
          
| 
               ¨ 
             | 
            
               Soliciting
      material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
      240.14a-12) 
             | 
          
| 
               ¨ 
             | 
            
               Pre-commencement
      communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR
      240.14d-2(b)) 
             | 
          
| 
               ¨ 
             | 
            
               Pre-commencement
      communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR
      240.13e-4(c)) 
             | 
          
| 
                 Number 
               | 
              
                 Description 
               | 
            |
| 
                 99.1 
               | 
              
                 Press
      Release on December 15, 2009 
               | 
            
| 
                       ORAGENICS,
      INC. 
                      (Registrant) 
                     | 
                  |||
| 
                       BY: 
                     | 
                          
                       /s/ David Hirsch 
                     | 
                    
                       | 
                  |
| 
                       David
      Hirsch 
                      President
      and Chief Executive
Officer 
                     | 
                  |||