FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
BONFIGLIO JOHN N
   2. Issuer Name and Ticker or Trading Symbol
ORAGENICS INC [OGEN] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
President and CEO
(Last)
(First)
(Middle)
3000 BAYPORT DRIVE, SUITE 685		 3. Date of Earliest Transaction (Month/Day/Year)
10/23/2012
(Street)

TAMPA, FL 33607		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 10/23/2012   A   56,482 (1) (2) A $ 0 183,818 D  
Common Stock 10/23/2012   F   14,939 (3) D $ 2.1 168,879 D  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
BONFIGLIO JOHN N
3000 BAYPORT DRIVE
SUITE 685
TAMPA, FL 33607		   X     President and CEO  

Signatures

 /s/ Mark A. Catchur, as Attorney-in-Fact for John N. Bonfiglio   10/25/2012
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Represents the portion of an aggregate performance award of 188,482 shares made in connection with, and as part of, the previously approved long term incentive compensation component of the executive compensation program adopted by the Company and made pursuant to an award agreement with the reporting individual. The award was originally made under the Company's Amended and Restated 2002 Stock Option and Incentive Plan (the "Plan") and was based upon the determination that the specified performance goal related to the Company's securing financing had been achieved. The initial award determination was made on August 6, 2012, pursuant to which 132,000 shares were awarded to the reporting person. The closing price of the Company's stock on such date was $ 2.75. (Continued in footnote 2)
(2) The balance of the performance award shares due of 56,482 was subject to shareholder approval of an amendment, restatement, and retitling of the Plan as well as an increase in the shares available for awards under the Plan, which occurred at the Company's annual meeting on October 23, 2012. The closing price of the Company's stock on October 23, 2012 was $2.10.
(3) Represents withholding of shares of common stock to satisfy tax withholding obligations in connection with the issuance of the balance of the performance share award.

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