Oragenics, Inc.

4902 Eisenhower Boulevard, Suite

Tampa, Florida 33634

January 23, 2023

VIA EDGAR

United States Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attn: Lauren Hamill

	Re:	Oragenics, Inc. (the “Company”)
		Registration Statement on Form S-3
		File No. 333-269225
		Request for Acceleration

Dear Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant (the “Registrant”) respectfully requests that the Securities and Exchange Commission take appropriate action to cause the above referenced Registration Statement on Form S-3 (the “Registration Statement”) to be declared effective at 4:00 p.m., Eastern Time, on Wednesday, January 25, 2023, or as soon thereafter as is practicable.

Once the Registration Statement has been declared effective, please orally confirm that event with Mark Catchur of Shumaker, Loop & Kendrick, LLP at (813) 227-2264. Thank you for your assistance in this matter.

	Very truly yours,

	/s/ Kimberly Murphy
	Kimberly Murphy
	President and Chief Executive Officer

cc:	Mark A. Catchur, Shumaker, Loop & Kendrick, LLP