Exhibit 23.1

            Consent of Independent Registered Public Accounting Firm

         We  consent  to  the   incorporation  by  reference  in  the  following
Registration Statements:

         (i)      Form S-8 No.  333-110646  pertaining to  Oragenics,  Inc. 2002
                  Stock Incentive Plan; and

         (ii)     Post Effective  Amendment No. 1 to the Registration  Statement
                  on  Form  S-3  to  Form  SB-2  (No.  333-100568)  and  related
                  Prospectus of Oragenics,  Inc. for the registration of 297,724
                  shares of its common stock issuable upon exercise of warrants;

of our report dated January 28, 2005,  with respect to the financial  statements
of  Oragenics,  Inc.  included in this Annual  Report (Form 10-KSB) for the year
ended December 31, 2004.

                                        /s/ Ernst & Young LLP
                                        Certified Public Accountants
Tampa, Florida
February 28, 2005