Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the inclusion in this Annual Report (Form 10-K) of Oragenics, Inc. of our report dated March 25, 2011, with respect to the 2010 financial statements of Oragenics, Inc. We consent to the incorporation by reference in the Form S-8 Registration Statements (Nos. 333-110646, 333-150716 and 333-163083) of Oragenics, Inc. pertaining to the Oragenics, Inc. Amended and Restated 2002 Stock Incentive Plan;


/s/ Mayer Hoffman McCann P.C.
Certified Public Accountants
Clearwater, Florida
March 25, 2011