Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the inclusion in this Annual Report (Form 10-K) of Oragenics, Inc. of our report dated March 29, 2019, with respect to the 2018 and 2017 financial statements of Oragenics, Inc. We consent to the incorporation of our report by reference in the following Registration Statements:



Form S-8 Registration Statements (Nos. 333-110646, 333-150716, 333-163083, 333-177091, 333-184588, 333-223088 and 333-225894) of Oragenics, Inc. pertaining to the Oragenics, Inc. 2012 Equity Incentive Plan; and



Registration Statements (Form S-1 Nos. 333-224498, 333-224950 and 333-226150) and (Form S-3 Nos. 333-183685, 333-190609, 333-213321 and 333-230422) and related Prospectus of Oragenics, Inc.

/s/ Mayer Hoffman McCann P.C.

Clearwater, Florida

March 29, 2019