Washington, D.C.  20549

FORM 12b-25

(Check One):

o Form 10-K   o Form 20-F    o Form 11-K
x Form 10-Q   o Form 10-D   o Form N-SAR   o Form N-CSR

For Period Ended:  March 31, 2009

o    Transition Report on Form 10-K
o    Transition Report on Form 20-F
o    Transition Report on Form 11-K
o    Transition Report on Form 10-Q
o    Transition Report on Form N-SAR
For the transition period ended: ______________________________

Nothing in this form shall be construed to imply that the Commission has verified any information contained herein.

If the notification relates to a portion of the filing checked above, identify the item(s) to which the notification relates:



Full Name of Registrant: Oragenics, Inc.

Former Name if Applicable: N/A                                                   

Address of Principal Executive Office (Street and Number): 13700 Progress Blvd.

City, State and Zip Code:  Alachua, Florida 32615 


RULE 12b-25(b) AND (c)

If the subject report could not be filed without unreasonable effort or expense and the registrant seeks relief pursuant to Rule 12b-25(b), the following should be completed.  (Check box if appropriate.)

The reasons described in reasonable detail in Part III of this form could not be eliminated without unreasonable effort or expense;

The subject annual report, semi-annual report, transition report on Form 10-K, Form 20-F, Form 11-K, Form N-SAR, or Form N-CSR, or portion thereof, will be filed on or before the fifteenth calendar day following the prescribed due date; or the subject quarterly report or transition report on Form 10-Q, or portion thereof, will be filed on or before the fifth calendar day following the prescribed due date; and

The accountant’s statement or other exhibit required by Rule 12b-25(c) has been attached if applicable.


State below in reasonable detail the reasons why the Forms 10-K, 20-F, 11-K, 10-Q, 10-D, N-SAR, N-CSR, or the transition report or portion thereof, could not be filed within the prescribed time period.

The Company’s Form 10-Q for the quarter ended March 31, 2009 could not be completed by the Company without unreasonable effort or expense due to the Company’s significantly limited financial resources at the present time. While the Company expects its Form 10-Q to be filed within the next five days, there can be no assurance that it will be able to do so.


(1)           Name and telephone number of person to contact in regard to this notification
David Hirsch
(386) 418-4018
(Area Code) (Telephone Number)
(2)           Have all other periodic reports required under Section 13 or 15(d) of the Securities Exchange Act of 1934 or Section 30 of the Investment Company Act of 1940 during the preceding 12 months or for such shorter period that the registrant was required to file such report(s) been filed?  If answer is no, identify report(s).
x Yes  o No

(3)           Is it anticipated that any significant change in results of operations from the corresponding period for the last fiscal year will be reflected by the earnings statements to be included in the subject report or portion thereof?
 o Yes  x No

If so, attach an explanation of the anticipated change, both narratively and quantitatively, and, if appropriate, state the reasons why a reasonable estimate of the results cannot be made.


Oragenics, Inc.
(Name of Registrant as Specified in Charter)

Has caused this notification to be signed on its behalf by the undersigned thereunto duly authorized.

Date: May 15, 2009
/s/ David Hirsch  
    By:  David Hirsch  
    Title: Acting Chief Executive Officer