4. Prepaid Expenses - Current and Long-Term

Prepaid expenses and other current assets were $1.6 million as of December 31, 2025, compared to $0.6 million as of December 31, 2024. The increase was primarily due to the timing of insurance premiums from financing our new policy renewals and advance payments related to research and development service agreements associated with the ONP-002 program.

The Company’s prepaid balances typically consist of insurance premiums, research and development service agreements, and other vendor advances aligned with ongoing clinical, manufacturing, and regulatory activities.