Annual report pursuant to Section 13 and 15(d)

Income Taxes (Details Textual)

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Income Taxes (Details Textual) (USD $)
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Income Taxes (Textual) [Abstract]      
Valuation Allowance $ 19,195,192 $ 14,315,214  
Net change in valuation allowance related to deferred tax assets 4,879,978 2,545,834  
Change in ownership 50.00%    
Annual amount of pre-change net operating losses 172,000    
Additional unrecognized tax benefits 329,676 59,967  
Tax positions 880,638 550,962 490,995
Interest and penalties 0 0  
Income tax benefit computed at statutory federal rate 34.00% 34.00%  
Research and Development Tax Credit [Member]
     
Income Tax Disclosure [Line Items]      
Federal research and development tax credit carryforwards 881,000    
Federal tax credit carryforward 2023    
Federal and State Tax [Member]
     
Income Tax Disclosure [Line Items]      
Federal and state tax net operating loss carryforwards $ 48,822,000    
Federal and state tax loss carryforward expiration date 2033