Annual report pursuant to Section 13 and 15(d)

Income Taxes (Details Narrative)

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Income Taxes (Details Narrative) - USD ($)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Income Tax Disclosure [Line Items]      
Valuation allowance $ 36,580,962 $ 30,098,339  
Net change in valuation allowance related to deferred tax assets 6,482,623 3,873,976  
Federal and state tax net operating loss carryforwards 142,893,000    
Additional unrecognized tax benefits 1,129,848 503,944  
Tax positions $ 4,042,705 $ 2,804,721 $ 2,249,594
Research and Development [Member]      
Income Tax Disclosure [Line Items]      
Net operating loss carryforwards description The federal tax credit carryforward will expire beginning in 2021 and continuing through 2040, unless previously utilized.    
Federal research and development tax credit carryforwards $ 4,043,000    
Federal And State Tax [Member]      
Income Tax Disclosure [Line Items]      
Net operating loss carryforwards description Federal and state of Florida tax net operating loss carryforwards generated prior to December 31, 2017 will expire through 2037.