Annual report pursuant to Section 13 and 15(d)

Statements of Changes in Shareholders' Equity

Statements of Changes in Shareholders' Equity - USD ($)	Total	Series A Preferred Stock [Member]	Series B Preferred Stock [Member]	Series C Preferred Stock [Member]	Common Stock [Member]	Preferred Stock [Member]	Preferred Stock [Member] Series A Preferred Stock [Member]	Preferred Stock [Member] Series B Preferred Stock [Member]	Preferred Stock [Member] Series C Preferred Stock [Member]	Stock Subscription Receivable [Member]	Additional Paid In Capital [Member]	Additional Paid In Capital [Member] Series A Preferred Stock [Member]	Additional Paid In Capital [Member] Series B Preferred Stock [Member]	Additional Paid In Capital [Member] Series C Preferred Stock [Member]	Accumulated Deficit [Member]
Beginning Balances at Dec. 31, 2015	$ 4,731,025				$ 3,986						$ 92,383,007				$ (87,655,968)
Beginning Balances, Shares at Dec. 31, 2015					3,986,767
Issuance of common stock	2,640,147				$ 905					$ (2,000,000)	4,639,242
Issuance of common stock, Shares					904,568
Repayment of stock subscription	1,969,437									1,969,437
Compensation expense relating to option issuances	472,780										472,780
Compensation expense relating to issuance of restricted shares	14,438				$ 3						14,435
Compensation expense relating to issuance of restricted shares, shares					3,000
Issuance of restricted common stock	151,200				$ 18						151,182
Issuance of restricted common stock, Shares					18,000
Net loss	(7,013,304)														(7,013,304)
Ending Balances at Dec. 31, 2016	$ 2,965,723				$ 4,912					(30,563)	97,660,646				(94,669,272)
Ending Balances, Shares at Dec. 31, 2016	4,912,335				4,912,335
Repayment of stock subscription	$ 30,563									$ 30,563
Compensation expense relating to option issuances	435,216										435,216
Issuance of preferred stock and warrants, net of expenses		$ 2,865,304	$ 3,253,175				$ 1,245,508	$ 1,679,301				$ 1,619,796	$ 1,573,874
Issuance of preferred stock and warrants, net of expenses, Shares							12,000,000	6,600,000
Issuance of Series C preferred stock, net of expenses				$ 3,372,591					$ 3,384,799					$ (12,208)
Issuance of Series C preferred stock, net of expenses, Shares									100
Compensation expense relating to issuance of restricted shares	2,062										2,062
Issuance of restricted common stock	123,200				$ 16						123,184
Issuance of restricted common stock, Shares					16,000
Net loss	(6,731,525)														(6,731,525)
Ending Balances at Dec. 31, 2017	$ 6,316,309				$ 4,928	$ 6,309,608					$ 101,402,570				$ (101,400,797)
Ending Balances, Shares at Dec. 31, 2017	4,928,335				4,928,335	18,600,100