Annual report pursuant to Section 13 and 15(d)

Commitments and Contingencies - Additional Information (Detail)

Commitments and Contingencies - Additional Information (Detail)	1 Months Ended				12 Months Ended
	Nov. 30, 2017 USD ($)	Oct. 31, 2017	Nov. 30, 2016 USD ($) ft²	Oct. 31, 2013 USD ($) ft²	Dec. 31, 2017 USD ($) Milestone
Alachua Facility [Member]
Commitment And Contingencies [Line Items]
Period of expired lease					3 years
Period of lease					5 years
Expiration period					Dec. 31, 2014
Rent expense					$ 131,000
Tampa Facility [Member]
Commitment And Contingencies [Line Items]
Period of lease			36 months	39 months
Expiration period			Feb. 29, 2020	Feb. 28, 2017
Rent expense					$ 56,000
Area of Office Space Leased \| ft²			2,207	4,168
Lease commencement date					Mar. 01, 2017
Minimum [Member] \| Alachua Facility [Member]
Commitment And Contingencies [Line Items]
Monthly lease payments					$ 9,641
Minimum [Member] \| Tampa Facility [Member]
Commitment And Contingencies [Line Items]
Monthly lease payments			$ 4,138	$ 6,426
Maximum [Member] \| Alachua Facility [Member]
Commitment And Contingencies [Line Items]
Monthly lease payments					$ 10,851
Maximum [Member] \| Tampa Facility [Member]
Commitment And Contingencies [Line Items]
Monthly lease payments			$ 4,392	$ 6,818
UFRF License Agreement [Member]
Commitment And Contingencies [Line Items]
Company's obligation to pay from percentage of selling price of product					5.00%
Company's obligation to pay from all revenue received from sublicenses					22.00%
One-time commercialization fee monthly amount for calculation					$ 5,000
Post-commercialization minimum royalty payments					50,000
One-time additional royalty payment would be due when total cumulative royalties paid to UFRF exceed amount					$ 2,000,000
One-time additional payment to UFRF as a percentage of total royalties due to UFRF					10.00%
Minimum annual maintenance payment on license agreement					$ 10,000
Quarterly maintenance payment to UFRF under installment plan					$ 2,500
Termination notice period					90 days
Texas A and M University License [Member]
Commitment And Contingencies [Line Items]
Company's obligation to pay from percentage of selling price of product					5.00%
Post-commercialization minimum royalty payments					$ 100,000
Termination notice period					90 days
Initial payment to Texas A&M					$ 5,000
Minimum consideration for the continuation of the license agreement					$ 15,000
Number of milestones achieved \| Milestone					0
Texas A and M University License [Member] \| Amendment [Member]
Commitment And Contingencies [Line Items]
Minimum consideration for the continuation of the license agreement					$ 25,000
Texas A and M University License [Member] \| Phase 1 Clinical Trial [Member]
Commitment And Contingencies [Line Items]
Date of milestone achievement under licensing agreement with Texas A&M					Jun. 01, 2019
Milestone payment under licensing agreement					$ 50,000
Texas A and M University License [Member] \| Phase 2 Clinical Trial [Member]
Commitment And Contingencies [Line Items]
Date of milestone achievement under licensing agreement with Texas A&M					Jun. 01, 2022
Milestone payment under licensing agreement					$ 100,000
Texas A and M University License [Member] \| Phase 3 Clinical Trial [Member]
Commitment And Contingencies [Line Items]
Date of milestone achievement under licensing agreement with Texas A&M					Jun. 01, 2025
Milestone payment under licensing agreement					$ 150,000
Texas A and M University License [Member] \| Sale Of Licensed Technology [Member]
Commitment And Contingencies [Line Items]
Date of milestone achievement under licensing agreement with Texas A&M					Jun. 01, 2026
Milestone payment under licensing agreement					$ 400,000
Texas A and M University License [Member] \| Minimum [Member]
Commitment And Contingencies [Line Items]
Company's obligation to pay from percentage of selling price of product					2.00%
Lantibiotic ECC [Member]
Commitment And Contingencies [Line Items]
Company's obligation to pay from percentage of selling price of product					10.00%
Company's obligation to pay from all revenue received from sublicenses	25.00%				25.00%
Termination notice period					90 days
Number of milestones achieved \| Milestone					0
Royalty rate reduced percentage of product profit	25.00%
Royalty rate reduced percentage of net sales	10.00%
Lantibiotic ECC [Member] \| Scenario, Previously Reported [Member]
Commitment And Contingencies [Line Items]
Company's obligation to pay from all revenue received from sublicenses		50.00%
Lantibiotic ECC [Member] \| Regulatory Approval Application Milestone Event [Member]
Commitment And Contingencies [Line Items]
Milestone payment under licensing agreement					$ 25,000,000
Milestone measurement period					6 months
Lantibiotic ECC [Member] \| New Indication Milestone Event [Member]
Commitment And Contingencies [Line Items]
Milestone payment under licensing agreement					$ 5,000,000
Milestone measurement period					6 months
Lantibiotic ECC [Member] \| New Product Milestone Event [Member]
Commitment And Contingencies [Line Items]
Milestone payment under licensing agreement					$ 5,000,000
Milestone measurement period					6 months
Lantibiotic ECC [Member] \| New Drug Application [Member]
Commitment And Contingencies [Line Items]
Milestone payment under licensing agreement	$ 25,000,000
Milestone measurement period	6 months
Lantibiotic ECC [Member] \| Minimum [Member]
Commitment And Contingencies [Line Items]
Advancement expended amount for lantibiotic program	$ 1,200,000
Oral Mucositis ECC [Member]
Commitment And Contingencies [Line Items]
Company's obligation to pay from percentage of selling price of product					12.00%
Company's obligation to pay from all revenue received from sublicenses	25.00%				25.00%
Termination notice period					90 days
Number of milestones achieved \| Milestone					0
Oral Mucositis ECC [Member] \| Scenario, Previously Reported [Member]
Commitment And Contingencies [Line Items]
Company's obligation to pay from all revenue received from sublicenses		50.00%
Oral Mucositis ECC [Member] \| Regulatory Approval Application Milestone Event [Member]
Commitment And Contingencies [Line Items]
Milestone payment under licensing agreement					$ 27,500,000
Milestone measurement period					6 months
Oral Mucositis ECC [Member] \| New Indication Milestone Event [Member]
Commitment And Contingencies [Line Items]
Milestone payment under licensing agreement					$ 5,000,000
Milestone measurement period					6 months
Oral Mucositis ECC [Member] \| New Product Milestone Event [Member]
Commitment And Contingencies [Line Items]
Milestone payment under licensing agreement					$ 5,000,000
Milestone measurement period					6 months
Oral Mucositis ECC [Member] \| New Product Application [Member]
Commitment And Contingencies [Line Items]
Milestone payment under licensing agreement	$ 27,500,000
Milestone measurement period	6 months
Oral Mucositis ECC [Member] \| Maximum [Member]
Commitment And Contingencies [Line Items]
Maturity of interest bearing promissory note					12 months