Annual report pursuant to Section 13 and 15(d)

Statements of Changes in Shareholders' Equity

Statements of Changes in Shareholders' Equity - USD ($)	Total	Series A Preferred Stock [Member]	Series B Preferred Stock [Member]	Series C Preferred Stock [Member]	Series D Preferred Stock [Member]	Common Stock [Member]	Common Stock [Member] Series A Preferred Stock [Member]	Common Stock [Member] Series D Preferred Stock [Member]	Preferred Stock [Member]	Preferred Stock [Member] Series A Preferred Stock [Member]	Preferred Stock [Member] Series B Preferred Stock [Member]	Preferred Stock [Member] Series C Preferred Stock [Member]	Preferred Stock [Member] Series D Preferred Stock [Member]	Stock Subscription Receivable [Member]	Additional Paid In Capital [Member]	Additional Paid In Capital [Member] Series A Preferred Stock [Member]	Additional Paid In Capital [Member] Series B Preferred Stock [Member]	Additional Paid In Capital [Member] Series C Preferred Stock [Member]	Additional Paid In Capital [Member] Series D Preferred Stock [Member]	Accumulated Deficit [Member]	Accumulated Deficit [Member] Series C Preferred Stock [Member]
Beginning Balances at Dec. 31, 2016	$ 2,965,723					$ 4,912								$ (30,563)	$ 97,660,646					$ (94,669,272)
Beginning Balances, Shares at Dec. 31, 2016						4,912,335
Repayment of stock subscription	30,563													$ 30,563
Compensation expense relating to option issuances	435,216														435,216
Issuance of stock and warrants, net of expenses		$ 2,865,304	$ 3,253,175							$ 1,245,508	$ 1,679,301					$ 1,619,796	$ 1,573,874
Issuance of stock and warrants, net of expenses, Shares										12,000,000	6,600,000
Issuance of Series C preferred stock, net of expenses				$ 3,372,591								$ 3,384,799						$ (12,208)
Issuance of Series C preferred stock, net of expenses, Shares												100
Compensation expense relating to issuance of restricted shares	2,062														2,062
Issuance of restricted common stock	123,200					$ 16									123,184
Issuance of restricted common stock, Shares						16,000
Net loss	(6,731,525)																			(6,731,525)
Ending Balances at Dec. 31, 2017	$ 6,316,309					$ 4,928			$ 6,309,608						101,402,570					(101,400,797)
Ending Balances, Shares at Dec. 31, 2017	4,928,335					4,928,335			18,600,100
Compensation expense relating to option issuances	$ 996,038														996,038
Issuance of common stock - shelf takedown, net of expenses	1,510,327					$ 900									1,509,427
Issuance of common stock - shelf takedown, net of expenses, Shares						900,000
Conversion of preferred stock to common stock							$ 258	$ 9,364		$ (268,096)			$ (4,464,107)			$ 267,838			$ 4,454,743
Conversion of preferred stock to common stock, Shares							258,300	9,364,000		(2,583,000)			(9,364,000)
Issuance of stock and warrants, net of expenses					$ 12,431,629	$ 4,436							$ 4,464,107						$ 7,963,086
Issuance of stock and warrants, net of expenses, Shares						4,436,000							9,364,000
Warrant exercises	9,505,501					$ 9,506									9,495,995
Warrant exercises, Shares						9,505,500
Series C dividend												$ 58,670									$ (58,670)
Series C dividend, Shares												2
Issuance of restricted common stock	24,320					$ 16									24,304
Issuance of restricted common stock, Shares						16,000
Issuance of common stock in exchange for services	12,000					$ 25									11,975
Issuance of common stock in exchange for services, Shares						25,000
Net loss	(9,914,141)																			(9,914,141)
Ending Balances at Dec. 31, 2018	$ 20,881,983					$ 29,433			$ 6,100,182						$ 126,125,976					$ (111,373,608)
Ending Balances, Shares at Dec. 31, 2018	29,433,135					29,433,135			16,017,102